Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2

Summary: Histone deacetylases (HDACs) drive innate immune cell-mediated inflammation. Here we identify class IIa HDACs as key molecular links between Toll-like receptor (TLR)-inducible aerobic glycolysis and macrophage inflammatory responses. A proteomic screen identified the glycolytic enzyme pyruv...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Kaustav Das Gupta, Melanie R. Shakespear, James E.B. Curson, Ambika M.V. Murthy, Abishek Iyer, Mark P. Hodson, Divya Ramnath, Vikas A. Tillu, Jessica B. von Pein, Robert C. Reid, Kathryn Tunny, Daniel M. Hohenhaus, Shayli Varasteh Moradi, Gregory M. Kelly, Takumi Kobayashi, Jennifer H. Gunter, Alexander J. Stevenson, Weijun Xu, Lin Luo, Alun Jones, Wayne A. Johnston, Antje Blumenthal, Kirill Alexandrov, Brett M. Collins, Jennifer L. Stow, David P. Fairlie, Matthew J. Sweet
Format:	Article
Language:	English
Published:	Elsevier 2020-02-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124720301613