A registry-based study on universal screening for defective mismatch repair in colorectal cancer in Denmark highlights disparities in screening uptake and counselling referrals

Universal screening for defective mismatch repair (dMMR) in colorectal cancer utilizes immunohistochemical staining for MLH1, MSH2, MSH6 and PSM2. Additionally, BRAF V600E mutations status and MLH1 hypermethylation should be performed to distinguish germline and somatic dMMR alterations. A decade of...

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出版年:	Translational Oncology
主要な著者:	Jon Ambæk Durhuus, Michael Galanakis, Thomas Maltesen, Christina Therkildsen, Susanne Rosthøj, Louise Laurberg Klarskov, Charlotte Kvist Lautrup, Ove Andersen, Mef Christina Nilbert
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2024-08-01
主題:	Lynch syndrome Reflex testing Colorectal cancer DNA mismatch repair Immunohistochemistry
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S1936523324001402