Serum and Glucocorticoid-Inducible Kinase 3/Nedd4-2 Signaling Pathway Participates in Podocyte Injury by Regulating the Stability of Nephrin

Serum and glucocorticoid-inducible kinase 3 (SGK3) is involved in maintaining podocyte function by regulating the protein levels of podocin and CD2-associated protein. Nephrin is also one of the slit diaphragm proteins of podocytes, but whether SGK3 participates in podocyte injury by regulating the...

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Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Qing-Qing Dong, Zi-Fang Li, Hui Zhang, Hua-Pan Shu, Yu-Chi Tu, Qian-Qian Liao, Li-Jun Yao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-01-01
Subjects:	SGK3 nephrin ubiquitin-proteasome degradation Nedd4-2 adriamycin podocytes
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2021.810473/full