Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator

Abstract Organismal physiology is widely regulated by the molecular circadian clock, a feedback loop composed of protein complexes whose members are enriched in intrinsically disordered regions. These regions can mediate protein-protein interactions via SLiMs, but the contribution of these disordere...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Meaghan S. Jankowski, Daniel Griffith, Divya G. Shastry, Jacqueline F. Pelham, Garrett M. Ginell, Joshua Thomas, Pankaj Karande, Alex S. Holehouse, Jennifer M. Hurley
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-04-01
Online Access:	https://doi.org/10.1038/s41467-024-47761-z