Targeting heparan sulfate-protein interactions with oligosaccharides and monoclonal antibodies

Heparan sulfate-binding proteins (HSBPs) are structurally diverse extracellular and membrane attached proteins that interact with HS under normal physiological conditions. Interactions with HS offer an additional level of control over the localization and function of HSBPs, which enables them to beh...

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Bibliographic Details

Published in:	Frontiers in Molecular Biosciences
Main Authors:	Miaomiao Li, Lars C. Pedersen, Ding Xu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-05-01
Subjects:	heparan sulfate binding proteins drug target oligosaccharide monoclonal antibody crystallization specificity
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2023.1194293/full