Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids

Pancreatic ductal adenocarcinomas (PDAC) exhibit complex morphologies challenging to capture in organoid models. Here, the authors develop PDAC organoids that can recreate branched structures and, with the use of a minimal mathematical model, shed light to pathways and processes directing the dynami...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	S. Randriamanantsoa, A. Papargyriou, H. C. Maurer, K. Peschke, M. Schuster, G. Zecchin, K. Steiger, R. Öllinger, D. Saur, C. Scheel, R. Rad, E. Hannezo, M. Reichert, A. R. Bausch
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-09-01
Online Access:	https://doi.org/10.1038/s41467-022-32806-y