Novel antimicrobial 3-phenyl-4-phenoxypyrazole derivatives target cell wall lipid intermediates with low mammalian cytotoxicity

Abstract The growing crisis of antimicrobial resistance (AMR) underscores the critical need for innovative antimicrobial discoveries. Novel antibiotics targeting the bacterial cell wall remain an attractive area of research, due to their conservation and essentiality in bacteria and their absence in...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Blanca Fernandez-Ciruelos, Marco Albanese, Femke Taverne, Paul W. Finn, Jerry M. Wells
Format: Article
Language:English
Published: Nature Portfolio 2025-10-01
Online Access:https://doi.org/10.1038/s41598-025-19561-y