REV7: a small but mighty regulator of genome maintenance and cancer development

REV7, also known as MAD2B, MAD2L2, and FANCV, is a HORMA-domain family protein crucial to multiple genome stability pathways. REV7’s canonical role is as a member of polymerase ζ, a specialized translesion synthesis polymerase essential for DNA damage tolerance. REV7 also ensures accurate cell cycle...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Lara R. Maggs, Mitch McVey
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Subjects:	REV7 genome stability DNA damage response cancer chemotherapeutic resistance chromatin
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1516165/full