Electrostatics of salt-dependent reentrant phase behaviors highlights diverse roles of ATP in biomolecular condensates

Liquid-liquid phase separation (LLPS) involving intrinsically disordered protein regions (IDRs) is a major physical mechanism for biological membraneless compartmentalization. The multifaceted electrostatic effects in these biomolecular condensates are exemplified here by experimental and theoretica...

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Bibliographic Details

Published in:	eLife
Main Authors:	Yi-Hsuan Lin, Tae Hun Kim, Suman Das, Tanmoy Pal, Jonas Wessén, Atul Kaushik Rangadurai, Lewis E Kay, Julie D Forman-Kay, Hue Sun Chan
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2025-03-01
Subjects:	liquid-liquid phase separation phosphorylation intrinsically disordered proteins random phase approximation field-theoretic simulation molecular dynamics
Online Access:	https://elifesciences.org/articles/100284