The tumour microenvironment of pilocytic astrocytoma evolves over time via enrichment for microglia

Abstract Pilocytic astrocytoma (PA) is the commonest low-grade tumour affecting children and is frequently experienced as a chronic disease associated with extended treatment, periods of regrowth, and long-term disability. This contrasts with the view of PA as a benign tumour with positive clinical...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	Thomas J. Stone, Jessica C. Pickles, Olumide Ogunbiyi, Shireena A. Yasin, Catherine A. Taylor, Saira W. Ahmed, Jane Chalker, Carryl Dryden, Iwona Slodkowska, Emily Pang, Mark Kristiansen, Rachel Williams, Helena Tutill, Charlotte A. Williams, Gaganjit K. Madhan, Leysa Forrest, Tony Brooks, Mike Hubank, Debbie Hughes, Paula Proszek, Grzegorz Pietka, Erin Peat, Darren Hargrave, Thomas S. Jacques
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Subjects:	Low-grade glioma Pilocytic astrocytoma Microglia Immune microenvironment
Online Access:	https://doi.org/10.1186/s40478-024-01922-9