Lung mitochondrial DNA copy number, inflammatory biomarkers, gene transcription and gene methylation in vapers and smokers

Summary: Background: Mitochondrial DNA copy number (mtCN) maintains cellular function and homeostasis, and is linked to nuclear DNA methylation and gene expression. Increased mtCN in the blood is associated with smoking and respiratory disease, but has received little attention for target organ eff...

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Bibliographic Details

Published in:	EBioMedicine
Main Authors:	Kellie M. Mori, Joseph P. McElroy, Daniel Y. Weng, Sangwoon Chung, Paolo Fadda, Sarah A. Reisinger, Kevin L. Ying, Theodore M. Brasky, Mark D. Wewers, Jo L. Freudenheim, Peter G. Shields, Min-Ae Song
Format:	Article
Language:	English
Published:	Elsevier 2022-11-01
Subjects:	Mitochondria copy numbers Smokers Vaping DNA methylation Gene expression Inflammation
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396422004832