Dynamic reciprocal interactions between activated T cells and tumor associated macrophages drive macrophage reprogramming and proinflammatory T cell migration within prostate tumor models

Abstract Tumor-associated macrophages (TAMs) have been implicated as a tumor microenvironment (TME) cell population, which may be playing a vital role in the inhibition of effective T cell responses in the prostate TME. In this manuscript, we leverage a novel microscale cell culture platform, known...

Full description

Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Erika Heninger, Matthew Thomas Breneman, Emma Elizabeth Recchia, Sheena Catherine Kerr, Reyna Elvan Dogru, Marina Nasrin Sharifi, Aaron Matthew LeBeau, David Kosoff
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-10-01
Subjects:	Tumor microenvironment TAM T cells Macrophage Co-culture
Online Access:	https://doi.org/10.1038/s41598-024-75265-9