Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel

Desensitization in pentameric ligand-gated ion channels plays an important role in regulating neuronal excitability. Here, we show that docosahexaenoic acid (DHA), a key ω−3 polyunsaturated fatty acid in synaptic membranes, enhances the agonist-induced transition to the desensitized state in the pro...

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Bibliographic Details

Published in:	eLife
Main Authors:	Sandip Basak, Nicolaus Schmandt, Yvonne Gicheru, Sudha Chakrapani
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2017-03-01
Subjects:	Cys-loop receptors allosteric modulation nanodiscs site-directed spin labeling
Online Access:	https://elifesciences.org/articles/23886