SIRT1-mediated deacetylation of FOXO3 enhances mitophagy and drives hormone resistance in endometrial cancer

Abstract Background The complex interplay between Sirtuin 1 (SIRT1) and FOXO3 in endometrial cancer (EC) remains understudied. This research aims to unravel the interactions of deacetylase SIRT1 and transcription factor FOXO3 in EC, focusing on their impact on mitophagy and hormone resistance. Metho...

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Bibliographic Details
Published in:Molecular Medicine
Main Authors: Xuehua Wei, Xiangpeng Xiong, Pingping Wang, Shufang Zhang, Dongxian Peng
Format: Article
Language:English
Published: BMC 2024-09-01
Subjects:
Endometrial cancer
SIRT1
FOXO3
Mitophagy
Hormone resistance
Deacetylation modification
Online Access:https://doi.org/10.1186/s10020-024-00915-7

Internet

https://doi.org/10.1186/s10020-024-00915-7

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