TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy

Mislocalization of the TAR DNA-binding protein 43 (TDP-43; encoded by TARDBP) from the nucleus to the cytoplasm is a common feature of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The downstream in vivo cellular effects of thi...

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發表在:	Disease Models & Mechanisms
Main Authors:	Rachel Atkinson, Jacqueline Leung, James Bender, Matthew Kirkcaldie, James Vickers, Anna King
格式:	Article
語言:	英语
出版:	The Company of Biologists 2021-02-01
主題:	tdp-43 amyotrophic lateral sclerosis frontotemporal lobar degeneration neurodegeneration disease model visual system
在線閱讀:	http://dmm.biologists.org/content/14/2/dmm047548