Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers

Affinity maturation is a complex dynamical process allowing the immune system to generate antibodies capable of recognizing antigens. We introduce a model for the evolution of the distribution of affinities across the antibody population in germinal centers. The model is amenable to detailed mathema...

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Bibliographic Details

Published in:	eLife
Main Authors:	Marco Molari, Klaus Eyer, Jean Baudry, Simona Cocco, Rémi Monasson
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2020-06-01
Subjects:	affinity maturation B-cell antigen dosage statistical inference systems modeling
Online Access:	https://elifesciences.org/articles/55678