LDHB Deficiency Promotes Mitochondrial Dysfunction Mediated Oxidative Stress and Neurodegeneration in Adult Mouse Brain

Age-related decline in mitochondrial function and oxidative stress plays a critical role in neurodegeneration. Lactate dehydrogenase-B (LDHB) is a glycolytic enzyme that catalyzes the conversion of lactate, an important brain energy substrate, into pyruvate. It has been reported that the LDHB patter...

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出版年:	Antioxidants
主要な著者:	Jun Sung Park, Kamran Saeed, Myeung Hoon Jo, Min Woo Kim, Hyeon Jin Lee, Chan-Bae Park, Gwang Lee, Myeong Ok Kim
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2022-01-01
主題:	Lactate dehydrogenase-B mitochondrial dysfunction oxidative stress inflammation p-AMPK/Sirt1/PGC-1alpha signaling osmotin
オンライン･アクセス:	https://www.mdpi.com/2076-3921/11/2/261