Codon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation

Abstract Background Cells regulate protein synthesis in response to fluctuating nutrient availability through mechanisms that affect both translation initiation and elongation. Branched-chain amino acids, leucine, isoleucine, and valine, are essential nutrients. However, how their depletion affects...

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Bibliographic Details

Published in:	Genome Biology
Main Authors:	Lina Worpenberg, Cédric Gobet, Felix Naef
Format:	Article
Language:	English
Published:	BMC 2025-09-01
Subjects:	Translation regulation Ribosome profiling Amino acid starvation tRNA charging Codon-specific stalling Elongation bottleneck
Online Access:	https://doi.org/10.1186/s13059-025-03800-6