NanoAbLLaMA: construction of nanobody libraries with protein large language models

IntroductionTraditional methods for constructing synthetic nanobody libraries are labor-intensive and time-consuming. This study introduces a novel approach leveraging protein large language models (LLMs) to generate germline-specific nanobody sequences, enabling efficient library construction throu...

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Bibliographic Details

Published in:	Frontiers in Chemistry
Main Authors:	Xin Wang, Haotian Chen, Bo Chen, Lixin Liang, Fengcheng Mei, Bingding Huang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Subjects:	reinforcement learning generative AI nanobodies libraries protein large language models
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2025.1545136/full