ITGB6 promotes tumor recurrence and metastasis by mediating the resistance of daughter cells of PGCCs to anoikis

Abstract Relapse and metastasis of malignancy remain the primary causes of treatment failure. Our prior research has revealed that polyploid giant cancer cells (PGCCs), these specialized dormant cells, are capable of triggering cancer recurrence and widespread metastasis. Once awakening, these PGCCs...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Si Pan, Huiting Liu, Haijuan Xiao, Ling yuan, Kaiwen Zhang, Haimeng Yin, Yumo Han, Rui Wu, Tian Xia, Zhenxin Zhang, Bo You
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-09-01
Subjects:	Tumor PGCCs HNSCCs Tumor recurrence Metastasis Anoikis
Online Access:	https://doi.org/10.1038/s41598-025-18652-0