Cell identity dynamics and insight into insulin secretagogues when employing stem cell-derived islets for disease modeling

Stem cell-derived islets (SC-islets) are not only an unlimited source for cell-based therapy of type 1 diabetes but have also emerged as an attractive material for modeling diabetes and conducting screening for treatment options. Prior to SC-islets becoming the established standard for disease model...

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Bibliographic Details

Published in:	Frontiers in Bioengineering and Biotechnology
Main Authors:	Chencheng Wang, Shadab Abadpour, Aleksandra Aizenshtadt, Andrea Dalmao-Fernandez, Merete Høyem, Ingrid Wilhelmsen, Justyna Stokowiec, Petter Angell Olsen, Stefan Krauss, Simona Chera, Luiza Ghila, Helge Ræder, Hanne Scholz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-06-01
Subjects:	stem cell derived beta cells insulin secretagogues disease modeling pyruvate kinase (pk) tri-hormonal cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2024.1392575/full