Edaravone dexborneol protected neurological function by targeting NRF2/ARE and NF-κB/AIM2 pathways in cerebral ischemia/reperfusion injury

BackgroundEdaravone dexborneol (Eda-Dex), a promising neuroprotectant composed of edaravone and (+)-borneol, has been clinically applied in stroke treatment. However, the mechanism of action of Eda-Dex remains unclear.MethodsA rat model of cerebral ischemia/reperfusion injury (CIRI) was created thro...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Frontiers in Pharmacology
المؤلفون الرئيسيون: Hui Zhang, Can Zhu, Xingyu Zhou, Laifa Wang, Ling Deng, Binsheng He, Jianming Li
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Frontiers Media S.A. 2025-04-01
الموضوعات:
edaravone dexborneol
neuroprotection
Nrf2/ARE pathway
NF-κB/AIM2 pathway
cerebral ischemia/reperfusion injury
الوصول للمادة أونلاين:https://www.frontiersin.org/articles/10.3389/fphar.2025.1581320/full

الانترنت

https://www.frontiersin.org/articles/10.3389/fphar.2025.1581320/full

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