Modulation of B cell activation threshold mediated by BCR/CD40 costimulation by targeting Cbl-b for ubiquitination

It has been shown that CD40 is required for optimal B cell activation. Casitas-B-lineage lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, inhibits B cell activation. In this report, we demonstrate that CD40 stimulation markedly enhances IgM-induced B cell proliferation in wild-type (WT) mice,...

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Bibliographic Details

Published in:	Biochemistry and Biophysics Reports
Main Authors:	Na Tang, Lifen Yang, Dongdong Li, Rushi Liu, Jian Zhang
Format:	Article
Language:	English
Published:	Elsevier 2019-07-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405580819300512