Ileal Crohn’s Disease Exhibits Reduced Activity of Phospholipase C-β3-Dependent Wnt/β-Catenin Signaling Pathway

Crohn’s disease is a chronic, debilitating, inflammatory bowel disease. Here, we report a critical role of phospholipase C-β3 (PLC-β3) in intestinal homeostasis. In PLC-β3-deficient mice, exposure to oral dextran sodium sulfate induced lethality and severe inflammation in the small intestine. The le...

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Bibliographic Details

Published in:	Cells
Main Authors:	Tomoaki Ando, Ikuo Takazawa, Zachary T. Spencer, Ryoji Ito, Yoshiaki Tomimori, Zbigniew Mikulski, Kenji Matsumoto, Tohru Ishitani, Lee A. Denson, Yu Kawakami, Yuko Kawakami, Jiro Kitaura, Yashi Ahmed, Toshiaki Kawakami
Format:	Article
Language:	English
Published:	MDPI AG 2024-06-01
Subjects:	phospholipase C-β3 inflammatory bowel disease Wnt/β-catenin signaling KO mouse Drosophila
Online Access:	https://www.mdpi.com/2073-4409/13/11/986