Synthesis and Preliminary Evaluation of an ASGPr-Targeted Polycationic <i>β</i>-Cyclodextrin Carrier for Nucleosides and Nucleotides

Most antiviral and anticancer nucleosides are prodrugs that require stepwise phosphorylation to their triphosphate nucleotide form for biological activity. Monophosphorylation may be rate-limiting, and the nucleotides may be unstable and poorly internalized by target cells. Effective targeting and d...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Jang-Ha Ryu, Weizhong Zheng, Xiao-Hong Yang, Hassan Elsaidi, Jim Diakur, Leonard I. Wiebe
Format:	Article
Language:	English
Published:	MDPI AG 2024-02-01
Subjects:	antiviral nucleosides arabinosyl adenine (araA, vidarabine) arabinosyl adenine 5′-monophosphate (araAMP) asialoglycoprotein receptor (ASGPr) beta-cyclodextrin (CyD) endocytic receptors
Online Access:	https://www.mdpi.com/1999-4923/16/3/323