Hypothermic machine perfusion prevents hyperacute graft loss in pig-to-primate kidney xenotransplantation after 5-hours of cold Ischemia

Abstract Background Xenotransplantation (XTx) is a promising strategy to address the organ shortage. Clinical application will likely require off-site procurement from designated pathogen-free (DPF) facilities, introducing unavoidable cold ischemic time (CIT). The impact of CIT and organ preservatio...

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Bibliographic Details

Published in:	Communications Medicine
Main Authors:	Yu Hisadome, Daniel L. Eisenson, WeiLi Chen, Alexander C. Schulick, Adam Luo, Michelle R. Santillan, Kelly Casella, Du Gu, Mitsuhiro Sekijima, Hisashi Sahara, Daniel Warren, Andrew Cameron, Hayato Iwase, Eugene Shenderov, Kazuhiko Yamada
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-04-01
Online Access:	https://doi.org/10.1038/s43856-025-00842-6