The structural integrity of human TFF1 under reducing conditions

The trefoil factor family (TFF) comprises three secretory peptides (TFF1, TFF2, TFF3) that regulate diverse physiological processes to maintain gastrointestinal mucosal integrity and homeostasis. The TFF domain is stabilized by six conserved cysteine residues forming three intramolecular disulfide b...

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Bibliographic Details

Published in:	Redox Biology
Main Authors:	Dilsah Nur Elmaci, Gene Hopping, Werner Hoffmann, Markus Muttenthaler, Matthias Stein
Format:	Article
Language:	English
Published:	Elsevier 2025-04-01
Subjects:	Trefoil factor family Disulfide bond stability Reductive stability Molecular dynamics simulation
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231725000473