Derivatizing Agent Selection for Hydrophilic Lysine- and Arginine-Containing Tetradecapeptide Analysis in Human Plasma by RP HPLC-MS/MS

The application of high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS) in the analysis of peptide therapeutics demonstrates its capacity to achieve high sensitivity and selectivity, which are essential qualities for the expanding peptide therapeutic industry. Given the...

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Bibliographic Details

Published in:	Analytica
Main Authors:	Margarita A. Tokareva, Evgeny S. Melnikov, Elizaveta N. Fisher, Tatiana A. Rodina, Igor E. Shohin, Maria V. Belova
Format:	Article
Language:	English
Published:	MDPI AG 2025-07-01
Subjects:	peptide HPLC-MS/MS derivatization optimization of chromatographic systems HEP-1
Online Access:	https://www.mdpi.com/2673-4532/6/3/23