Negative feedback buffers effects of regulatory variants

Abstract Mechanisms conferring robustness against regulatory variants have been controversial. Previous studies suggested widespread buffering of RNA misexpression on protein levels during translation. We do not find evidence that translational buffering is common. Instead, we find extensive bufferi...

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Bibliographic Details

Published in:	Molecular Systems Biology
Main Authors:	Daniel M Bader, Stefan Wilkening, Gen Lin, Manu M Tekkedil, Kim Dietrich, Lars M Steinmetz, Julien Gagneur
Format:	Article
Language:	English
Published:	Springer Nature 2015-01-01
Subjects:	buffering canalization cis regulation feedback trans regulation
Online Access:	https://doi.org/10.15252/msb.20145844