PEACOCK: a machine learning approach to assess the validity of cell type-specific enhancer-gene regulatory relationships

Abstract The vast majority of disease-associated variants identified in genome-wide association studies map to enhancers, powerful regulatory elements which orchestrate the recruitment of transcriptional complexes to their target genes’ promoters to upregulate transcription in a cell type- and timin...

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Bibliographic Details
Published in:npj Systems Biology and Applications
Main Authors: Caitlin Mills, Crystal N. Marconett, Juan Pablo Lewinger, Huaiyu Mi
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Online Access:https://doi.org/10.1038/s41540-023-00270-z