Designing of an Efficient Whole-Cell Biocatalyst System for Converting L-Lysine Into Cis-3-Hydroxypipecolic Acid

Cis-3-hydroxypipecolic acid (cis-3-HyPip), a key structural component of tetrapeptide antibiotic GE81112, which has attracted substantial attention for its broad antimicrobial properties and unique ability to inhibit bacterial translation initiation. In this study, a combined strategy to increase th...

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Bibliographic Details

Published in:	Frontiers in Microbiology
Main Authors:	Shewei Hu, Yangyang Li, Alei Zhang, Hui Li, Kequan Chen, Pingkai Ouyang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Subjects:	ribosome binding sites tricarboxylic acid cycle reconstitute α-ketoglutarate whole-cell catalysis
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2022.945184/full