Gut microbiota-derived indoleacetic acid attenuates neuroinflammation and neurodegeneration in glaucoma through ahr/rage pathway

Abstract Background Gut microbiota has emerged as a promising therapeutic target for neurodegenerative disorders through regulation of neuroinflammatory responses, while its role in optic nerve degeneration remains incompletely characterized. This study elucidates the neuroprotective role of gut mic...

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Bibliographic Details

Published in:	Journal of Neuroinflammation
Main Authors:	Ning Wang, Chengyang Sun, Yijie Yang, Dandan Zhang, Lulu Huang, Chenrui Xu, Minghan Wang, Mengmeng Xu, Tongtong Yan, Yue Wu, Li Xu, Yahan Ju, Hao Sun, Wenyi Guo
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Subjects:	Gut microbiota-eye axis Glaucoma Neuroinflammation Tryptophan metabolites AhR Microglia
Online Access:	https://doi.org/10.1186/s12974-025-03505-4