Impaired xCT-mediated cystine uptake drives serine and proline metabolic reprogramming and mitochondrial fission in skeletal muscle cells

Muscle satellite cell (MuSC) proliferation is tightly regulated by redox homeostasis and nutrient availability, which are often disrupted in muscular pathologies. Beyond its role in maintaining cellular redox homeostasis, this study identified a key metabolic role for cystine/glutamate antiporter xC...

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Bibliographic Details

Published in:	Redox Biology
Main Authors:	Michel N. Kanaan, Charbel Y. Karam, Luke S. Kennedy, Chantal A. Pileggi, Lauren Hamilton, Miroslava Cuperlovic-Culf, Mary-Ellen Harper
Format:	Article
Language:	English
Published:	Elsevier 2025-10-01
Subjects:	Slc7a11 Cystine/glutamate antiporter System Xc− Metabolic reprogramming Cysteine Proline
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231725003520