New UPLC–MS/MS assay for the determination of tamoxifen and its metabolites in human plasma, application to patients

Aim: A rapid UPLC–MS/MS method for the determination of tamoxifen (TAM), N-desmethyltamoxifen, 4-hydroxytamoxifen and endoxifen in human plasma was validated, after a simple protein precipitation. Materials and methods: The analysis was achieved on a C18 analytical column, using a gradient elution w...

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Bibliographic Details

Published in:	Future Science OA
Main Authors:	Christine Bobin-Dubigeon, Mario Campone, Elsa Rossignol, Estelle Salaun, Marie-Bernadette Amiand, Jean-Marie Bard
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2019-06-01
Subjects:	analytical method endoxifen 4-hydroxytamoxifen N desmethyl tamoxifen plasma tamoxifen
Online Access:	https://www.future-science.com/doi/10.2144/fsoa-2018-0113