ABT-737 induces Bim expression via JNK signaling pathway and its effect on the radiation sensitivity of HeLa cells.

ABT-737 is a BH3 mimetic small molecule inhibitor that can effectively inhibit the activity of antiapoptotic Bcl-2 family proteins including Bcl2, Bcl-xL and Bcl-w, and further enhances the effect of apoptosis by activating the proapoptotic proteins (t-Bid, Bad, Bim). In this study, we demonstrate t...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Huan Wang, Yue-Bo Yang, Hui-Min Shen, Jian Gu, Tian Li, Xiao-Mao Li
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23285061/pdf/?tool=EBI