FMRP silencing via siRNA lipid nanoparticles to reprogram the tumor microenvironment and enhance anti-PD-1 efficacy in triple-negative breast cancer

Fragile X mental retardation protein (FMRP), encoded by the Fmr1 gene, is notably upregulated in various malignancies, including triple-negative breast cancer, pancreatic ductal adenocarcinoma, and colon carcinoma, and potentially mediates immune evasion through multiple mechanisms. Here a small int...

Full description

Bibliographic Details

Published in:	Materials Today Bio
Main Authors:	Letian Bai, Xinyan Hao, Wenjie Xu, Hai Huang, Mengen Guo, Yanwen Zhang, Daxiong Xiang, Guoping Yang, Junyong Wu, Chuanpin Chen
Format:	Article
Language:	English
Published:	Elsevier 2025-08-01
Subjects:	Lipid nanoparticle (LNP) Fragile X mental retardation protein (FMRP) siRNA delivery PD-1 Tumor microenvironment Immunotherapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590006425006453