Poly(rC)-binding proteins as pleiotropic regulators in hematopoiesis and hematological malignancy

Poly(rC)-binding proteins (PCBPs), a defined subfamily of RNA binding proteins, are characterized by their high affinity and sequence-specific interaction with poly-cytosine (poly-C). The PCBP family comprises five members, including hnRNP K and PCBP1-4. These proteins share a relatively similar str...

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Bibliographic Details
Published in:Frontiers in Oncology
Main Authors: Huijuan Zhao, Ziqing Wei, Guomin Shen, Yixiang Chen, Xueqin Hao, Sanqiang Li, Rong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Subjects:
poly(rC)-binding proteins
hematopoiesis
hematological malignancy
mRNA stability
alternative splicing
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1045797/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.1045797/full

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