A minimally invasive biomarker for sensitive and accurate diagnosis of Parkinson’s disease

Abstract Seeding activities of disease-associated α-synuclein aggregates (αSynD), a hallmark of Parkinson’s disease (PD), are detectable by seed amplification assay (αSyn-SAA) and being developed as a diagnostic biomarker for PD. Sensitive and accurate αSyn-SAA for blood or saliva would greatly faci...

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Bibliographic Details
Published in:Acta Neuropathologica Communications
Main Authors: Zerui Wang, Tricia Gilliland, Hyun Jo Kim, Maria Gerasimenko, Kailey Sajewski, Manuel V. Camacho, Gurkan Bebek, Shu G. Chen, Steven A. Gunzler, Qingzhong Kong
Format: Article
Language:English
Published: BMC 2024-10-01
Subjects:
Seeding activity
Alpha-synuclein
Parkinson’s disease
Biomarker
RT-QuIC
Online Access:https://doi.org/10.1186/s40478-024-01873-1

Internet

https://doi.org/10.1186/s40478-024-01873-1

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