Tumor microenvironment-responsive manganese-based nano-modulator activate the cGAS-STING pathway to enhance innate immune system response

Abstract Background Manganese ions (Mn2+) combined with adjuvants capable of damaging and lysing tumor cells form an antitumor nano-modulator that enhances the immune efficacy of cancer therapy through the cascade activation of the cyclic GMP-AMP interferon gene synthase-stimulator (cGAS-STING) path...

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Bibliographic Details

Published in:	Journal of Nanobiotechnology
Main Authors:	Xiayi Liang, Duo Wang, Yuanquan Zhao, Xiaobo Wang, Siyang Yao, Wei Huang, Yongyu Yang, Xiaofeng Dong, Lei Zhang, Jianrong Yang
Format:	Article
Language:	English
Published:	BMC 2024-09-01
Subjects:	Tumor microenvironment Innate immunity cGAS-STING pathway Manganese immunotherapy
Online Access:	https://doi.org/10.1186/s12951-024-02809-6