Co-translational protein aggregation and ribosome stalling as a broad-spectrum antibacterial mechanism

Abstract Drug-resistant bacteria pose an urgent global health threat, necessitating the development of antibacterial compounds with novel modes of action. Protein biosynthesis accounts for up to half of the energy expenditure of bacterial cells, and consequently inhibiting the efficiency or fidelity...

Full description

Bibliographic Details

Published in:	Nature Communications
Main Authors:	Laleh Khodaparast, Ladan Khodaparast, Ramon Duran-Romaña, Guiqin Wu, Bert Houben, Wouter Duverger, Matthias De Vleeschouwer, Katerina Konstantoulea, Fleur Nysen, Thomas Schalck, Daniel J. Curwen, Lisandra L. Martin, Sebastien Carpentier, Bernard Scorneaux, Jan Michiels, Joost Schymkowitz, Frederic Rousseau
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-02-01
Online Access:	https://doi.org/10.1038/s41467-025-56873-z