Transcriptome reveals the landscape of alveolar macrophages exposed to combined hypoxia with cigarette smoke extract

Abstract Background Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous chronic inflammatory disease that is one of the leading causes of age-standardised deaths globally. While studies have investigated altitude's effects on COPD, none have explored alveolar macrophage...

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Bibliographic Details

Published in:	Respiratory Research
Main Authors:	Qing Liu, Yushi Zhang, Ruirui Duan, Wanheng Li, Xuan Hou, Yiling Chen, Baicun Li, Ting Yang
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Subjects:	Chronic obstructive pulmonary disease Hypoxia Cigarette smoke extract HIF-1α Alveolar macrophage homeostasis
Online Access:	https://doi.org/10.1186/s12931-025-03303-9