The Effects of PPAR Stimulation on Cardiac Metabolic Pathways in Barth Syndrome Mice

Aim: Tafazzin knockdown (TazKD) in mice is widely used to create an experimental model of Barth syndrome (BTHS) that exhibits dilated cardiomyopathy and impaired exercise capacity. Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that play essential roles...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Caitlin Schafer, Vicky Moore, Nupur Dasgupta, Sabzali Javadov, Jeanne F. James, Alexander I. Glukhov, Arnold W. Strauss, Zaza Khuchua
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-04-01
Subjects:	PPAR agonist bezafibrate cardiomyopathy Ostn musclin Barth syndrome
Online Access:	http://journal.frontiersin.org/article/10.3389/fphar.2018.00318/full