Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration

Abstract Background The progression of Parkinson’s disease (PD) is related to ageing. The accumulation of nuclear alpha-synuclein (α-syn) may accelerate the occurrence of neurodegenerative diseases, but its role in PD remains poorly understood. Methods In the present study, α-syn expression was spec...

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Bibliographic Details
Published in:Immunity & Ageing
Main Authors: Tingfu Du, Guoxiang Li, Qinglan Zong, Haiyu Luo, Yue Pan, Kaili Ma
Format: Article
Language:English
Published: BMC 2024-07-01
Subjects:
Parkinson’s disease
Alpha-synuclein
Senescence
SASP
Inflammatory response
Loss of neurons
Online Access:https://doi.org/10.1186/s12979-024-00429-0

Internet

https://doi.org/10.1186/s12979-024-00429-0

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