Fractal analysis of extracellular matrix for observer-independent quantification of intestinal fibrosis in Crohn’s disease

Abstract Prevention of intestinal fibrosis remains an unresolved problem in the treatment of Crohn’s disease (CD), as specific antifibrotic therapies are not yet available. Appropriate analysis of fibrosis severity is essential for assessing the therapeutic efficacy of potential antifibrotic drugs....

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Marie-Christin Weber, Konstantin Schmidt, Annalisa Buck, Atsuko Kasajima, Simon Becker, Chunqiao Li, Stefan Reischl, Dirk Wilhelm, Katja Steiger, Helmut Friess, Philipp-Alexander Neumann
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-02-01
Subjects:	Crohn’s disease Intestinal fibrosis Histology Fractal dimension analysis
Online Access:	https://doi.org/10.1038/s41598-024-54545-4