LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis

The Parkinson’s disease (PD)-associated gene leucine-rich repeat kinase 2 (LRRK2) has been studied extensively in the brain. However, several studies have established that mutations in LRRK2 confer susceptibility to mycobacterial infection, suggesting LRRK2 also controls immunity. We demonstrate tha...

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Bibliographic Details

Published in:	eLife
Main Authors:	Chi G Weindel, Samantha L Bell, Krystal J Vail, Kelsi O West, Kristin L Patrick, Robert O Watson
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2020-02-01
Subjects:	parkinson's disease cGAS DRP1 purine biosynthesis bacterial pathogenesis metabolism
Online Access:	https://elifesciences.org/articles/51071