Bayesian modeling reveals metabolite‐dependent ultrasensitivity in the cyanobacterial circadian clock

Abstract Mathematical models can enable a predictive understanding of mechanism in cell biology by quantitatively describing complex networks of interactions, but such models are often poorly constrained by available data. Owing to its relative biochemical simplicity, the core circadian oscillator i...

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Bibliographic Details

Published in:	Molecular Systems Biology
Main Authors:	Lu Hong, Danylo O Lavrentovich, Archana Chavan, Eugene Leypunskiy, Eileen Li, Charles Matthews, Andy LiWang, Michael J Rust, Aaron R Dinner
Format:	Article
Language:	English
Published:	Springer Nature 2020-06-01
Subjects:	Bayes factor kinetic modeling Markov chain Monte Carlo robustness substrate competition
Online Access:	https://doi.org/10.15252/msb.20199355