Alterations to melanocortinergic, GABAergic and cannabinoid neurotransmission associated with olanzapine-induced weight gain.

Second generation antipsychotics (SGAs) are used to treat schizophrenia but can cause serious metabolic side-effects, such as obesity and diabetes. This study examined the effects of low to high doses of olanzapine on appetite/metabolic regulatory signals in the hypothalamus and brainstem to elucida...

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Bibliographic Details
Published in:PLoS ONE
Main Authors: Katrina Weston-Green, Xu-Feng Huang, Chao Deng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Online Access:http://europepmc.org/articles/PMC3306411?pdf=render