Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway

Eightly-four novel thioheterocyclic nucleoside derivatives were designed, synthesized, and evaluated for antitumor activity in vitro and in vivo. Most of the compounds inhibited the growth of HCT116 and HeLa cancer cells in vitro, among them 33a and 36b exhibited potent activity against HCT116 cells...

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Bibliographic Details

Published in:	Acta Pharmaceutica Sinica B
Main Authors:	Xian-Jia Li, Ke-Xin Huang, Ke-Xin Wang, Ru Liu, Dong-Chao Wang, Yu-Ru Liang, Er-Jun Hao, Yang Wang, Hai-Ming Guo
Format:	Article
Language:	English
Published:	Elsevier 2025-07-01
Subjects:	Thioheterocyclic nucleoside Structure–activity relationships Anti-proliferation activity Antitumor activity ROS Autophagy
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383525003144