Improved Process for the Synthesis of 3-(3-Trifluoromethylphenyl)propanal for More Sustainable Production of Cinacalcet HCl

Cinacalcet (<b>I</b>), sold as hydrochloride salt, is a calcimimetic drug which has been approved for the treatment of secondary hyperparathyroidism in patients with chronic renal disease and for the treatment of hypercalcemia in patients with parathyroid carcinoma. Here, an improved met...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Vikas Damu Rathod, Stefano Paganelli, Marijan Kočevar, Marko Krivec, Oreste Piccolo
Format:	Article
Language:	English
Published:	MDPI AG 2023-08-01
Subjects:	Pd catalyst cascade process C-C and C-H bond formation microwaves selective ester reduction
Online Access:	https://www.mdpi.com/1420-3049/28/16/6042