Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington disease

In Huntington disease (HD), the mutant huntingtin (mtHTT) protein is the principal cause of pathological changes that initiate primarily along the cortico-striatal axis. mtHTT is ubiquitously expressed and there is, accordingly, growing recognition that HD is a systemic disorder with functional inte...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Stefan Bartl, Yuanyun Xie, Nalini Potluri, Ratnesh Kesineni, Katlin Hencak, Louisa Dal Cengio, Katja Balazs, Abid Oueslati, Michela Parth, Nina Salhat, Alberto Siddu, Oskar Smrzka, Francesca Cicchetti, Günther Straffler, Michael R. Hayden, Amber L. Southwell
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Subjects:	Huntington disease Immunotherapy Passive immunization Huntingtin lowering therapy Extracellular huntingtin Transgenic mice
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996123003923